Bio Veintralex Capsules
Varicose veins are a result of chronic venous insufficiency of the lower limbs, which affects almost half of the population today. Varicose veins usually form in the legs causing an unaesthetic bluish grid, convex veins, accompanied by pain, swelling and heaviness. The problem concerns mainly mature women, but also many men and younger people increasingly complain about this condition. Varicose veins not only look ugly, but it are also a dangerous condition that can lead to severe complications, even life-threatening. That's why it's important to react at the first signs of developing the disease.
The flavonoids diosmin and hesperidin have been shown to strengthen blood vessels, improve venous tone, and increase lymphatic drainage. These and other flavonoids decrease synthesis of prostaglandin E2 (PGE2) and thromboxane A2 (TXA2).
1 capsule contains:
Diosmin is a semisynthetic phlebotropic nutritional supplement, a member of the flavonoid family. It is an oral phlebotropic nutritional supplementg used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. To control internal symptoms of hemorrhoids (piles), it is used with hesperidin.
Diosmin prolongs the vasoconstrictor effect of noradrenaline on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis. This increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.
Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries. Furthermore, diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.
At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.
Diosmin reduces the expression of endothelial adhesion molecules (ICAM1, VCAM1), and inhibits the adhesion, migration, and activation of leukocytes at the capillary level. This leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins (PGE2, PGF2a).
Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. In human nutrition it contributes to the integrity of the blood vessels.
Various preliminary studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. Hesperidin has anti-inflammatory effects.
Rutin, also called rutoside, quercetin-3-rutinoside and sophorin, is a citrus flavonoid glycoside found in buckwheat, the leaves and petioles of Rheum species, and the fruit of the Fava D'Anta tree (from Brazil), as well as other sources. Its name comes from the name of Ruta graveolens, a plant, that also contains rutin. Rutin is the glycoside between the flavonol quercetin and the disaccharide rutinose.
Rutin attaches to the iron ion Fe2+, preventing it from binding to hydrogen peroxide, which would otherwise create a highly-reactive free-radical that may damage cells. It is also an antioxidant, and therefore plays a role in inhibiting some cancers.
Rutin also strengthens the capillaries, and, therefore, can reduce the symptoms of haemophilia. It also may help to prevent a common unpleasant-looking venous edema of the legs. Rutin, as ferulic acid, can reduce the cytotoxicity of oxidized LDL cholesterol and lower the risk of heart disease.
Other names: Detralex, DIH, Diosminex, Diosminum